Dragoncharger Antiques has dated this Edo Period Enamel Netsuke to the 1850s.
Possibly the netsuke belonged to a doctor.

An early dimunitive and finely enamelled manju with enamels in turquoise, greens and yellow. An extremely rare Masterpiece, made by a highly skilled artisan in the early era of mastering cloisonne techniques in Japan.

Material: Wood Bowl with Champleve Cloisonne Enamel on Metal Lid
Condition: In excellent condition with some minor marks commensurate with age. No cracks or chips.
Size: 1.6" diameter (4.1 cm)
Weight: 0.7 oz (19 g)
Provenance:
Ryan Snooks collection of Japanese & Asian Decorative Art.
Dragoncharger Antiques has dated this Edo Period Enamel Netsuke to the 1850s.
Specialising in early japanese cloisonne, edo enamel artisan period.
You can view the stock and full dealer information on the Dragoncharger Antiques Profile Page